| Primary Identifier | MGI:7859532 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Modified regulatory region | Gene | Rr602 |
| Transmission | Germline | Strain of Origin | C57BL/6J-A<w-J>/J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The Gbx2 enhancer (GRCm39:chr1:89641474-89642633), located in an Agap1 intron, was replaced with the orthologous human enhancer (GRCh38:chr2:235864812-235866052). A loxP site flanked neomycin resistance gene cassette that was inserted was removed through subsequent Cre-mediated recombination. The human enhancer drives Gbx2 expression in human-specific expanded domains in the embryonic fore- and hindlimb buds. |
