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MP Term : abnormal stratum corneum lipid matrix formation [MP:0009596] Mammalian Phenotype

Namespace  MPheno.ontology Obsolete  false
description  altered lipid composition or intercellular lipid matrix assembly in the stratum corneum, usually resulting in loss of epidermal barrier function; normally, the intercorneocyte lipid matrix consists of a complex lipid mixture of ceramides, cholesterol and long-chain saturated fatty acids that self-assembles into an ordered multilayer structure known as lipid lamellae
  • synonyms:
  • abnormal intercorneocyte lipid lamellae,
  • defective epidermal lipid matrix composition,
  • abnormal intercorneocyte lamellar lipids,
  • abnormal stratum corneum extracellular lipid matrix,
  • epidermal lipid matrix defects
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