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DO Term : hemophagocytic lymphohistiocytosis [DOID:0050120] Disease Ontology

Namespace  disease_ontology Obsolete  false
description  A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.
  • synonyms:
  • OMIM:PS267700,
  • ICD10CM:D76.1,
  • MESH:D051359,
  • ORDO:540,
  • PS267700,
  • UMLS_CUI:C0024291,
  • NCI:C34792,
  • SNOMEDCT_US_2023_03_01:190958003,
  • GARD:6589,
  • haemophagocytic syndrome,
  • DOID:6453
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