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MP Term : abnormal liver sinusoidal endothelial cell morphology [MP:0031148] Mammalian Phenotype

Namespace  MPheno.ontology Obsolete  false
description  any structural anomaly of the endothelial cells that line the hepatic sinusoids, constituting the sinusoidal wall; these represent the most abundant non-parenchymal hepatic cell population, are characterized by the presence of fenestrae clustered in sieve plates and lacking a basement membrane, play roles in filtration, endocytosis, antigen presentation and leukocyte recruitment, and in combination with Kupffer cells, constitute a scavenger system in the body
  • synonyms:
  • abnormal LSEC morphology,
  • abnormal hepatic sinusoidal endothelial cell morphology,
  • abnormal HSEC morphology
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