Catalysis of the reaction: a catechol + S-adenosyl-L-methionine = a guaiacol + H+ + S-adenosyl-L-homocysteine. Acts on catechols and on catecholamines such as adrenaline or noradrenaline.
synonyms:
catecholamine O-methyltransferase activity,
catechol methyltransferase activity,
MB-COMT (membrane-bound form of catechol-O-methyltransferase),
COMT I,
S-COMT (soluble form of catechol-O-methyltransferase),
