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GO Term : hippo signaling [GO:0035329] Gene Ontology

Namespace

biological_process

Obsolete

false

description

An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.

synonyms:
hippo signal transduction,
SWH pathway,
hippo signalling cascade,
Salvador-Warts-Hippo signaling pathway,
hippo signaling cascade,
hippo signaling pathway

Function

Functions (GO terms and children) --> Mouse features

Functions (GO terms) --> Mouse features

Ontology

Ontology Term --> All ancestors

Ontology Term --> All descendants

Ontology Term --> Direct children

Ontology Term --> Direct parents

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