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GO Term : PCSK9-LDLR complex [GO:1990666] Gene Ontology

Namespace

cellular_component

Obsolete

false

description

A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.

synonyms:
PCSK9/LDL-R complex,
PCSK9.LDLR complex,
PCSK9:low-density lipoprotein receptor complex,
PCSK9:EGF-A complex

Function

Functions (GO terms and children) --> Mouse features

Functions (GO terms) --> Mouse features

Ontology

Ontology Term --> All ancestors

Ontology Term --> All descendants

Ontology Term --> Direct children

Ontology Term --> Direct parents

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