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Allele : Trp53<tm3Tyj> transformation related protein 53; targeted mutation 3, Tyler Jacks

Primary Identifier	MGI:3039265	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Trp53
Transmission	Germline	Strain of Origin	129S4/SvJae
Is Recombinase	false	Is Wild Type	false

molecularNote

A targeting construct was designed to insert a loxP flanked stop cassette into intron 1 and an R270H missense mutation into exon 8.

mutations:
Nucleotide substitutions,
Insertion

cellLines:
Not Specified

synonyms:
p53 LSL-R270H,
p53 LSL-R270H,
p53<LSL•R270H>,
p53<LSL-R270H>,
p53<LSL•R270H>,
p53<LSL-R270H>

earliestPublication:
Olive KP, et al. (2004) Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119(6):847-60

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

3 Carried By

43 Publication categories

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