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Comment :

Type  MGI:General Description  delayed differention of a central subpopulation of early, round proliferative chondrocytes (RPCs) into flat proliferative chondrocytes (FPCs) and thence into hypertrophic chondrocytes (HCs): whereas in humeri of wild-type embryos the HC layer is clearly defined at E13.5, in mutant embryos HCs are not observed until E15.5