| Type | MGI:General | Description | at E17.5 and E18.5, mutant mice exhibit excessive proliferation of differentiating cochlear HCs at E18.5, the upper basal turn of mutant cochleas shows a 6-fold increase in the numbers of HC nuclei relative to controls at birth, mutants display ectopic mitoses in the greater epithelial ridge and the region of cochlear IHCs and OHCs, not present in control mice most mitotic cochlear HCs are located near the lumen, while some are found in deeper epithelial layers increased mitotic activity and overproduction of cochlear HCs is first evident at E15.5 at E17.5 and E18.5, supernumerary cochlear HC production is partially compensated by increased apoptosis |
