| Type | MGI:General | Description | mutant sperm exhibited normal capacitation events, but failed to exhibit the expected intracellular [Ca2+]i mobilization in response to ZP progesterone, another physiological inducer of the acrosome reaction, failed to induce sustained [Ca2+]i increases in mutant sperm, also resulting in partial inhibition of the acrosome reaction finally, assessment of store-operated channel (SOC) function using thapsigargin indicated that capacitative Ca2+ entry through SOC channels was severely impaired in mutant sperm |
