| Type | MGI:General | Description | tumor lymph nodes exhibit an increase in the number of macrophages within the paracortex with occasional foci of myeloid metaplasia, dense aggregates of small PAX5+ lymphocytes all over the parenchyma forming follicles without germinal centers, reactive B-blasts and small clusters of mature plasma cells in the interfollicular areas, polymorphic infiltrate composed of small- to medium-sized proliferating CD3+ lymphocytes in the interfollicular compartment, T cells that occasionally form rosettes around large blasts, sinusoidal dilatation, vessels filled with T cells, an increase in the proportion of B cells, an increase in the frequency of myeloid and dendritic cells with monocyte-derived dendritic cells showing a 2- to 3-fold expansion, a decrease in CD8+ dendritic cells, and an increase in proliferation of follicular helper T cells nonenlarged lymph nodes from tumor-bearing heterozygotes exhibit preserved nodal architecture, having both primary and secondary follicles with reactive germinal centers as well as an increase of mature plasma cells in the interfollicular area |
