| First Author | Thompson B | Year | 2021 |
| Journal | Compr Physiol | Volume | 11 |
| Issue | 4 | Pages | 1-21 |
| PubMed ID | 34636409 | Mgi Jnum | J:329323 |
| Mgi Id | MGI:7343845 | Doi | 10.1002/cphy.c210004 |
| Citation | Thompson B, et al. (2021) Beta-Cell Ion Channels and Their Role in Regulating Insulin Secretion. Compr Physiol 11(4):1-21 |
| abstractText | Beta cells of the pancreatic islet express many different types of ion channels. These channels reside in the beta-cell plasma membrane as well as subcellular organelles and their coordinated activity and sensitivity to metabolism regulate glucose-dependent insulin secretion. Here, we review the molecular nature, expression patterns, and functional roles of many beta-cell channels, with an eye toward explaining the ionic basis of glucose-induced insulin secretion. Our primary focus is on KATP and voltage-gated Ca(2+) channels as these primarily regulate insulin secretion; other channels in our view primarily help to sculpt the electrical patterns generated by activated beta-cells or indirectly regulate metabolism. Lastly, we discuss why understanding the physiological roles played by ion channels is important for understanding the secretory defects that occur in type 2 diabetes. (c) 2021 American Physiological Society. Compr Physiol 11:1-21, 2021. |
