| First Author | Hijioka K | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 356 |
| Issue | 2 | Pages | 476-80 |
| PubMed ID | 17367755 | Mgi Jnum | J:121485 |
| Mgi Id | MGI:3710273 | Doi | 10.1016/j.bbrc.2007.03.002 |
| Citation | Hijioka K, et al. (2007) Induction of the nuclear IkappaB protein IkappaB-zeta upon stimulation of B cell antigen receptor. Biochem Biophys Res Commun 356(2):476-80 |
| abstractText | The nuclear IkappaB protein IkappaB-zeta is barely detectable in resting cells and is induced in macrophages and fibroblasts following stimulation of innate immunity via Toll-like receptors. The induced IkappaB-zeta associates with nuclear factor (NF)-kappaB in the nucleus and plays crucial roles in its transcriptional regulation. Here, we examined the induction of IkappaB-zeta in B lymphocytes, one of the major players in adaptive immunity. Upon crosslinking of the surface immunoglobulin complex, IkappaB-zeta mRNA was robustly induced in murine B-lymphoma cell line A20 cells. While the crosslinking activated NF-kappaB and induced its target gene, IkappaB-alpha, co-crosslinking of Fcgamma receptor IIB to the surface immunoglobulin complex inhibited NF-kappaB activation and the induction of IkappaB-zeta and IkappaB-alpha, suggesting critical roles for NF-kappaB in the induction. These results indicate that IkappaB-zeta is also induced by stimulation of B cell antigen receptor, suggesting that IkappaB-zeta is involved in the regulation of adaptive immune responses. |
