| First Author | Braun L | Year | 1999 |
| Journal | FEBS Lett | Volume | 463 |
| Issue | 3 | Pages | 345-9 |
| PubMed ID | 10606751 | Mgi Jnum | J:59058 |
| Mgi Id | MGI:1350852 | Doi | 10.1016/s0014-5793(99)01649-x |
| Citation | Braun L, et al. (1999) Different induction of gulonolactone oxidase in aromatic hydrocarbon-responsive or -unresponsive mouse strains. FEBS Lett 463(3):345-9 |
| abstractText | The role of aromatic hydrocarbon receptor (AhR)-mediated signal transduction pathways was investigated in the regulation of ascorbate synthesis by using Ah-responsive and Ah-unresponsive mouse strains. In vivo 3-methylcholanthrene treatment increased hepatic and plasma ascorbate concentrations only in the Ah-responsive strain. The mRNA level of gulonolactone oxidase and the microsomal ascorbate production from p-nitrophenyl glucuronide, D-glucuronic acid or gulonolactone in the liver of Ah-responsive and Ah-unresponsive mice were compared. In Ah-responsive mice, these parameters were higher originally, and they further increased upon in vivo addition of 3-methylcholanthrene, while in Ah-unresponsive mice the treatment was not effective. These results suggest that the transcription of gulonolactone oxidase gene is regulated by an Ah receptor-dependent signal transduction pathway. |
