| First Author | Pesce M | Year | 1998 |
| Journal | Mech Dev | Volume | 71 |
| Issue | 1-2 | Pages | 89-98 |
| PubMed ID | 9507072 | Mgi Jnum | J:46643 |
| Mgi Id | MGI:1201721 | Doi | 10.1016/s0925-4773(98)00002-1 |
| Citation | Pesce M, et al. (1998) Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Dev 71(1-2):89-98 |
| abstractText | The POU transcription factor Oct-4 is expressed in early mouse embryogenesis and in pluripotent ES and EC stem cell lines. After gastrulation in the embryo, Oct-4 expression is confined to the germline. The present study provides evidence that Oct-4 undergoes downregulation during oogenesis and spermatogenesis, coincident with entry into meiosis. Furthermore, analysis of maturation stages of oocytes showed that Oct-4 is upregulated de novo in the final stages of meiotic prophase I in female germ cells. These data suggest that Oct-4 downregulation in germ cells in both sexes might represent one of the molecular triggers involved in the commitment to meiosis. The upregulation of Oct-4 in oocytes at the completion of the prophase I of meiotic division further suggests a specific involvement of this transcription factor in oocyte growth or the acquisition of meiotic competence. |
