| First Author | Andersen B | Year | 1993 |
| Journal | Science | Volume | 260 |
| Issue | 5104 | Pages | 78-82 |
| PubMed ID | 7682011 | Mgi Jnum | J:130866 |
| Mgi Id | MGI:3772484 | Doi | 10.1126/science.7682011 |
| Citation | Andersen B, et al. (1993) Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors expressed in epidermis. Science 260(5104):78-82 |
| abstractText | Two forms of a member of the POU domain family of transcriptional regulators, highly related to Oct-2, are selectively expressed in terminally differentiating epidermis and hair follicles. One form, referred to as Skn-1i, contains an amino-terminal domain that inhibits DNA binding and can inhibit transactivation by Oct-1. A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression. The pattern of expression of the Skn-1a/i gene products and the effect of the alternative products on the expression of other genes suggest that these factors serve regulatory functions with respect to epidermal development. |
