| First Author | Yoshinari K | Year | 2003 |
| Journal | FEBS Lett | Volume | 548 |
| Issue | 1-3 | Pages | 17-20 |
| PubMed ID | 12885400 | Mgi Jnum | J:84681 |
| Mgi Id | MGI:2669024 | Doi | 10.1016/s0014-5793(03)00720-8 |
| Citation | Yoshinari K, et al. (2003) Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Lett 548(1-3):17-20 |
| abstractText | The nuclear receptor CAR, a phenobarbital (PB)-responsive transcription factor, translocates into the nucleus of hepatocytes after PB induction. In non-induced mice, CAR forms a physical complex with heat shock protein 90 (HSP90) in the cytoplasm. In response to PB induction, protein phosphatase 2A is recruited to the CAR:HSP90 complex. This recruitment may lead CAR to translocate into the nucleus, consistent with the inhibitions of nuclear CAR accumulation in PB-induced mouse primary hepatocytes by okadaic acid as well as by geldanamycin. |
