| First Author | Tucker AS | Year | 1999 |
| Journal | Development | Volume | 126 |
| Issue | 2 | Pages | 221-8 |
| PubMed ID | 9847236 | Mgi Jnum | J:51126 |
| Mgi Id | MGI:1314703 | Doi | 10.1242/dev.126.2.221 |
| Citation | Tucker AS, et al. (1999) Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development 126(2):221-8 |
| abstractText | Clim-2 (NLI, Lbd1) is one of two related mouse proteins that interact with Lim-domain homeoproteins. In the mouse, embryonic expression of Clim-2 is particularly pronounced in facial ectomesenchyme and limb bud mesenchyme in association with Lim genes, Lhx-6 and Lmx-1 respectively. We show that in common with both these Lim genes, Clim-2 expression is regulated by signals from overlying epithelium. In both the developing face and the limb buds we identify Fgf-8 as the likely candidate signalling molecule that regulates Clim-2 expression. We show that in the mandibular arch, as in the limb, Fgf-8 functions in combination with CD44, a cell surface binding protein, and that blocking CD44 binding results in inhibition of Fgf8-induced expression of Clim-2 and Lhx-6. Regulation of gene expression by Fgf8 in association with CD44 is thus conserved between limb and mandibular arch development. |
