| First Author | Carpenter S | Year | 2013 |
| Journal | Science | Volume | 341 |
| Issue | 6147 | Pages | 789-92 |
| PubMed ID | 23907535 | Mgi Jnum | J:199359 |
| Mgi Id | MGI:5502463 | Doi | 10.1126/science.1240925 |
| Citation | Carpenter S, et al. (2013) A long noncoding RNA mediates both activation and repression of immune response genes. Science 341(6147):789-92 |
| abstractText | An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors. We have identified a long noncoding RNA (lncRNA) that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce the expression of numerous lncRNAs. One of these, lincRNA-Cox2, mediates both the activation and repression of distinct classes of immune genes. Transcriptional repression of target genes is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response. |
