| First Author | Mandal M | Year | 2005 |
| Journal | J Exp Med | Volume | 201 |
| Issue | 4 | Pages | 603-14 |
| PubMed ID | 15728238 | Mgi Jnum | J:96628 |
| Mgi Id | MGI:3531056 | Doi | 10.1084/jem.20041924 |
| Citation | Mandal M, et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 201(4):603-14 |
| abstractText | The pre-T cell receptor (TCR) is expressed early during T cell development and imposes a tight selection for differentiating T cell progenitors. Pre-TCR-expressing cells are selected to survive and differentiate further, whereas pre-TCR(-) cells are 'negatively' selected to die. The mechanisms of pre-TCR-mediated survival are poorly understood. Here, we describe the induction of the antiapoptotic gene BCL2A1 (A1) as a potential mechanism regulating inhibition of pre-T cell death. We characterize in detail the signaling pathway involved in A1 induction and show that A1 expression can induce pre-T cell survival by inhibiting activation of caspase-3. Moreover, we show that in vitro 'knockdown' of A1 expression can compromise survival even in the presence of a functional pre-TCR. Finally, we suggest that pre-TCR-induced A1 overexpression can contribute to T cell leukemia in both mice and humans. |
