| First Author | Burkhardt C | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 17 | Pages | 3821-8 |
| PubMed ID | 15978582 | Mgi Jnum | J:99780 |
| Mgi Id | MGI:3583832 | Doi | 10.1016/j.febslet.2005.05.079 |
| Citation | Burkhardt C, et al. (2005) Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. FEBS Lett 579(17):3821-8 |
| abstractText | The semaphorins are a large family of proteins that act as guidance signals for axons and dendrites. The class 4 semaphorins are integral membrane proteins that are widely expressed throughout the nervous system. Here, we show that a subclass of these semaphorins is characterized by a PDZ-binding motif at their carboxy-terminus. This sequence mediates the interaction with the post-synaptic density protein PSD-95/SAP90. Co-expression of Sema4B with PSD-95 in COS 7 cells results in the clustering of Sema4B. Sema4B co-localizes with PSD-95 at synaptic contacts between cultured hippocampal neurons. This synaptic localization depends on the presence of the PDZ-binding motif. |
