| First Author | Martinowich K | Year | 2003 |
| Journal | Science | Volume | 302 |
| Issue | 5646 | Pages | 890-3 |
| PubMed ID | 14593184 | Mgi Jnum | J:86311 |
| Mgi Id | MGI:2679393 | Doi | 10.1126/science.1090842 |
| Citation | Martinowich K, et al. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302(5646):890-3 |
| abstractText | In conjunction with histone modifications, DNA methylation plays critical roles in gene silencing through chromatin remodeling. Changes in DNA methylation perturb neuronal function, and mutations in a methyl-CpG-binding protein, MeCP2, are associated with Rett syndrome. We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the Bdnf gene. Moreover, increased Bdnf transcription involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter. Our findings suggest that DNA methylation-related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity. |
