| First Author | Alland L | Year | 1997 |
| Journal | Nature | Volume | 387 |
| Issue | 6628 | Pages | 49-55 |
| PubMed ID | 9139821 | Mgi Jnum | J:40055 |
| Mgi Id | MGI:87394 | Doi | 10.1038/387049a0 |
| Citation | Alland L, et al. (1997) Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression [see comments]. Nature 387(6628):49-55 |
| abstractText | Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression. |
