| First Author | Kim JA | Year | 2012 |
| Journal | Biochem Biophys Res Commun | Volume | 421 |
| Issue | 3 | Pages | 591-8 |
| PubMed ID | 22525672 | Mgi Jnum | J:183994 |
| Mgi Id | MGI:5319713 | Doi | 10.1016/j.bbrc.2012.04.051 |
| Citation | Kim JA, et al. (2012) Feed-back regulation of disabled-2 (Dab2) p96 isoform for GATA-4 during differentiation of F9 cells. Biochem Biophys Res Commun 421(3):591-8 |
| abstractText | F9 embryonic carcinoma (EC) cells undergo extra-embryonic endodermal (ExE) differentiation in response to retinoic acid (RA) treatment, which induces the expression of two isoforms (p96 and p67) of the adaptor protein, Disabled-2 (Dab2). In the current study, constitutive and ectopic expression of the p96 isoform induced ExE differentiation in F9 EC cells in the absence of RA treatment via the activation of GATA-4 by p96. During the RA-induced differentiation process, Dab2 expression is induced by the GATA factors in a coherent feed-forward loop; on the other hand, we showed that p96 regulates GATA-4 in a positive feed-back manner in this study. Our results indicate that p96 Dab2 plays a key role in the ExE differentiation process. |
