| First Author | Suzuki Y | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 9 | Pages | 1403-8 |
| PubMed ID | 19376115 | Mgi Jnum | J:148014 |
| Mgi Id | MGI:3843380 | Doi | 10.1016/j.febslet.2009.04.014 |
| Citation | Suzuki Y, et al. (2009) An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor. FEBS Lett 583(9):1403-8 |
| abstractText | The gamma-secretase, composed of presenilin-1 (PS1) or presenilin-2 (PS2), nicastrin (NCT), anterior pharynx-defective phenotype 1 (APH-1), and PEN-2, is critical for the development of Alzheimer's disease (AD). PSs are autoproteolytically cleaved, producing an N-terminal fragment (NTF) and a hydrophilic loop domain-containing C-terminal fragment. However, the role of the loop domain in the gamma-secretase complex assembly remains unknown. Here, we report a novel PS2 isoform generated by alternative splicing, named PS2beta, which is composed of an NTF with a hydrophilic loop domain. PS2beta disturbed the interaction between NCT and APH-1, resulting in the inhibition of amyloid-beta production. We concluded that PS2beta may inhibit gamma-secretase activity by affecting the gamma-secretase complex assembly. |
