| First Author | Krebs AR | Year | 2010 |
| Journal | EMBO Rep | Volume | 11 |
| Issue | 7 | Pages | 541-7 |
| PubMed ID | 20508642 | Mgi Jnum | J:162104 |
| Mgi Id | MGI:4462751 | Doi | 10.1038/embor.2010.75 |
| Citation | Krebs AR, et al. (2010) ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. EMBO Rep 11(7):541-7 |
| abstractText | The Ada-Two-A-containing (ATAC) histone acetyltransferase and Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here, we report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. Moreover, we identify leucine zipper motif-containing protein 1 as a subunit of this meta-coactivator complex (MECO). Finally, we demonstrate that the MECO regulates a subset of RNA polymerase II-transcribed non-coding RNA genes. Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes. |
