| First Author | Sun L | Year | 1998 |
| Journal | Immunity | Volume | 8 |
| Issue | 6 | Pages | 703-11 |
| PubMed ID | 9655484 | Mgi Jnum | J:48252 |
| Mgi Id | MGI:1267102 | Doi | 10.1016/s1074-7613(00)80575-0 |
| Citation | Sun L, et al. (1998) Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. Immunity 8(6):703-11 |
| abstractText | Calcineurin plays a pivotal role in the T cell receptor (TCR)-mediated signal transduction pathway and serves as a common target for the immunosuppressants FK506 and cyclosporin A. We report the identification of a novel endogenous calcineurin binding protein named Cabin 1 that inhibits calcineurin-mediated signal transduction. The interaction between Cabin 1 and calcineurin is dependent on PKC activation. Overexpression of Cabin 1 or its N-terminal truncation mutants inhibits the transcriptional activation of calcineurin-responsive elements in the interleukin-2 promoter and blocks dephosphorylation of NF-AT upon T cell activation. These results suggest a negative regulatory role for Cabin 1 in calcineurin signaling and provide a possible mechanism of feedback inhibition of TCR signaling through cross-talk between protein kinases and calcineurin. |
