| First Author | Nguyen BC | Year | 2006 |
| Journal | Genes Dev | Volume | 20 |
| Issue | 8 | Pages | 1028-42 |
| PubMed ID | 16618808 | Mgi Jnum | J:108327 |
| Mgi Id | MGI:3623698 | Doi | 10.1101/gad.1406006 |
| Citation | Nguyen BC, et al. (2006) Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev 20(8):1028-42 |
| abstractText | Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 activation in both mouse and human keratinocytes through a mechanism independent of cell cycle withdrawal and requiring down-modulation of selected interferon-responsive genes, including IRF7 and/or IRF3. In turn, elevated p63 expression counteracts the ability of Notch1 to restrict growth and promote differentiation. p63 functions as a selective modulator of Notch1-dependent transcription and function, with the Hes-1 gene as one of its direct negative targets. Thus, a complex cross-talk between Notch and p63 is involved in the balance between keratinocyte self-renewal and differentiation. |
