| First Author | Zhi X | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 5 | Pages | 757-63 |
| PubMed ID | 24462679 | Mgi Jnum | J:206664 |
| Mgi Id | MGI:5551666 | Doi | 10.1016/j.febslet.2014.01.022 |
| Citation | Zhi X, et al. (2014) MiR-874 promotes intestinal barrier dysfunction through targeting AQP3 following intestinal ischemic injury. FEBS Lett 588(5):757-63 |
| abstractText | Intestinal ischemic injury is a significant clinical problem arising from diseases or as a complication of abdominal surgery. Our previous study showed aquaporin 3 is involved in intestinal barrier impairment. Here, we revealed that intestinal ischemia induced a time-dependent increase of miR-874 expression and a time-dependent decrease of AQP3 expression, and the level of miR-874 expression was inversely related to AQP3 protein expression. In addition, miR-874 promoted the paracellular permeability in vitro through targeting 3'UTR of AQP3. Two of the tight junction proteins, Occludin and Claudin-1, were found to be involved in miR-874-induced intestinal barrier dysfunction. |
