| First Author | Masuda N | Year | 1998 |
| Journal | Gene | Volume | 221 |
| Issue | 2 | Pages | 225-33 |
| PubMed ID | 9795230 | Mgi Jnum | J:50854 |
| Mgi Id | MGI:1312970 | Doi | 10.1016/s0378-1119(98)00461-2 |
| Citation | Masuda N, et al. (1998) Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. Gene 221(2):225-33 |
| abstractText | To identify the proteins which may modulate the functions of peroxisome proliferator-activated receptor (PPAR), a rat liver cDNA library was screened by a yeast two-hybrid system, using the mouse PPARalpha as a bait. A protein named nuclear receptor binding factor-1 (NRBF-1) was identified, which interacts not only with PPARalpha, but also with various nuclear hormone receptors in the presence of the respective ligands. Both the hinge and ligand-binding domains of PPARalpha are required for the interaction. NRBF-1 seems to be translocated to the nucleus by a piggyback mechanism, together with PPARalpha. NRBF-1 has a significant homology to the yeast protein MRF1, a putative transcription factor regulating the expression of mitochondrial respiratory proteins. NRBF-1 might be another type of nuclear receptor co-operator. |
