| First Author | Natale DR | Year | 2002 |
| Journal | Mech Dev | Volume | 119 Suppl 1 |
| Pages | S21-6 | PubMed ID | 14516655 |
| Mgi Jnum | J:81328 | Mgi Id | MGI:2448886 |
| Doi | 10.1016/s0925-4773(03)00086-8 | Citation | Natale DR, et al. (2002) Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development. Mech Dev 119 Suppl 1:S21-6 |
| abstractText | Adherens junction formation is fundamental for compaction and trophectoderm differentiation during mammalian preimplantation development. We recently isolated an IQGAP-2 cDNA from a differential display-polymerase chain reaction screen of bovine preimplantation developmental stages. IQGAP-1 and -2 proteins mediate E-cadherin-based cell-to-cell adhesion through interactions with beta-catenin and the Rho GTPases, rac1 and cdc42. Our study demonstrates IQGAP-1,-2, rac-1 and cdc42 mRNAs are present throughout murine preimplantation development. IQGAP-1 and rac-1 protein distribution changes from predominantly plasma membrane associated to predominantly cytoplasmic as the embryo progresses through cleavage divisions and compaction to the blastocyst stage. |
