| First Author | Herre J | Year | 2004 |
| Journal | Mol Immunol | Volume | 40 |
| Issue | 12 | Pages | 869-76 |
| PubMed ID | 14698225 | Mgi Jnum | J:87730 |
| Mgi Id | MGI:3027477 | Doi | 10.1016/j.molimm.2003.10.007 |
| Citation | Herre J, et al. (2004) Dectin-1 and its role in the recognition of beta-glucans by macrophages. Mol Immunol 40(12):869-76 |
| abstractText | beta-Glucans are well known leukocyte activators that have shown protective benefits in a variety of animal disease models, yet the mechanism of action of these carbohydrates remains unknown. We have shown that Dectin-1, a murine type II C-type lectin-like receptor, was able to non-opsonically recognize beta-1,3 and beta-1,6 linked glucan rich particles and intact yeast. Dectin-1 is widely expressed in murine tissues, particularly on the monocyte/macrophage and neutrophil lineages, on dendritic cells (DC) and at a lower level on a sub-population of T cells. The human homologue of Dectin-1 was identified and is functionally similar to the murine molecule. Human Dectin-1 differs from the murine molecule in that it is expressed as two major splice variants that are selectively expressed in particular leukocyte populations. In addition to beta-glucans, Dectin-1 also recognizes an endogenous ligand on T cells. The ligand and the immunological role of Dectin-1 mediated T cell interactions remain to be described. |
