| First Author | Hori S | Year | 2003 |
| Journal | Science | Volume | 299 |
| Issue | 5609 | Pages | 1057-61 |
| PubMed ID | 12522256 | Mgi Jnum | J:82045 |
| Mgi Id | MGI:2450778 | Doi | 10.1126/science.1079490 |
| Citation | Hori S, et al. (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299(5609):1057-61 |
| abstractText | Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naive T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+ regulatory T cells. Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells. |
