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Publication : p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice.

First Author  Higashi S Year  2015
Journal  Biochem Biophys Res Commun Volume  461
Issue  4 Pages  612-7
PubMed ID  25912136 Mgi Jnum  J:228369
Mgi Id  MGI:5706869 Doi  10.1016/j.bbrc.2015.04.074
Citation  Higashi S, et al. (2015) p13 overexpression in pancreatic beta-cells ameliorates type 2 diabetes in high-fat-fed mice. Biochem Biophys Res Commun 461(4):612-7
abstractText  We examined the pancreatic function of p13 encoded by 1110001J03Rik, whose expression is decreased in pancreatic islets in high-fat-fed diabetic mice, by generating transgenic mice overexpressing p13 (p13-Tg) in pancreatic beta-cells. p13-Tg mice showed normal basal glucose metabolism; however, under high-fat feeding, these animals showed augmented glucose-induced first-phase and total insulin secretion, improved glucose disposal, greater islet area and increased mitotic insulin-positive cells. In addition, high-fat diet-induced 4-hydroxynonenal immunoreactivity, a reliable marker and causative agent of lipid peroxidative stress, was significantly decreased in p13-Tg mouse islets. These results indicate that p13 is a novel pancreatic factor exerting multiple beneficial effects against type 2 diabetes.
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