| First Author | Chern JJ | Year | 2002 |
| Journal | Development | Volume | 129 |
| Issue | 17 | Pages | 4005-13 |
| PubMed ID | 12163404 | Mgi Jnum | J:78416 |
| Mgi Id | MGI:2384376 | Doi | 10.1242/dev.129.17.4005 |
| Citation | Chern JJ, et al. (2002) Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc. Development 129(17):4005-13 |
| abstractText | Notch (N) activation at the dorsoventral (DV) boundary of the Drosophila eye is required for early eye primordium growth. Despite the apparent DV mirror symmetry, some mutations cause a preferential loss of the ventral domain, suggesting that the growth of individual domains is asymmetrically regulated. We show that the Lobe (L) gene is required non-autonomously for ventral growth but not dorsal growth, and that it mediates the proliferative effect of midline N signaling in a ventral-specific manner. L encodes a novel protein with a conserved domain. Loss of L suppresses the overproliferation phenotype of constitutive N activation in the ventral, but not in the dorsal eye, and gain of L rescues ventral tissue loss in N mutant background. Furthermore, L is necessary and sufficient for the ventral expression of a N ligand, Serrate (Ser), which affects ventral growth. Our data suggest that the control of ventral Ser expression by L represents a molecular mechanism that governs asymmetrical eye growth. |
