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Publication : Expression of Nogo protein by growing axons in the developing nervous system.

First Author  Tozaki H Year  2002
Journal  Brain Res Mol Brain Res Volume  104
Issue  2 Pages  111-9
PubMed ID  12225863 Mgi Jnum  J:79814
Mgi Id  MGI:2388965 Doi  10.1016/s0169-328x(02)00172-9
Citation  Tozaki H, et al. (2002) Expression of Nogo protein by growing axons in the developing nervous system. Brain Res Mol Brain Res 104(2):111
abstractText  We produced monoclonal antibody NG1 that strongly binds growing axons in the developing nervous system of mice. This antibody intensely labeled the growth cone of cultured neurons. Although these immunostaining patterns suggested the association of growing axons with the antigen recognized by this antibody, the antigen was identified as Nogo protein, an axonal repulsive factor isolated from the myelin. On the basis of this unexpected finding, we discuss the possible functions of Nogo in the developing nervous system.
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