| First Author | Bessho Y | Year | 2003 |
| Journal | Genes Dev | Volume | 17 |
| Issue | 12 | Pages | 1451-6 |
| PubMed ID | 12783854 | Mgi Jnum | J:83945 |
| Mgi Id | MGI:2664435 | Doi | 10.1101/gad.1092303 |
| Citation | Bessho Y, et al. (2003) Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev 17(12):1451-6 |
| abstractText | Hes7, a bHLH gene essential for somitogenesis, displays cyclic expression of mRNA in the presomitic mesoderm (PSM). Here, we show that Hes7 protein is also expressed in a dynamic manner, which depends on proteasome-mediated degradation. Spatial comparison revealed that Hes7 and Lunatic fringe (Lfng) transcription occurs in the Hes7 protein-negative domains. Furthermore, Hes7 and Lfng transcription is constitutively up-regulated in the absence of Hes7 protein and down-regulated by stabilization of Hes7 protein. Thus, periodic repression by Hes7 protein is critical for the cyclic transcription of Hes7 and Lfng, and this negative feedback represents a molecular basis for the segmentation clock. |
