| First Author | Aida S | Year | 1995 |
| Journal | Int J Immunother | Volume | 11 |
| Issue | 3 | Pages | 107-113 |
| Mgi Jnum | J:31377 | Mgi Id | MGI:78878 |
| Citation | Aida S, et al. (1995) Calcitonin affects the expression of adhesion molecules on T-cell receptor (TCR) cells. Int J Immunother 11(3):107-113 |
| abstractText | An immunosuppressive effect of calcitonin (CT) in rheumatoid arthritis (RA) patients has been demonstrated. Effects of CT on T cells were studied by observing the expression of CD3 and TCR (alpha beta and gamma delta) as well as adhesion molecules (CD44, L-selectin, ICAM-1 and LFA-1) on T cells after CT treatment in C3H mice, using flow cytometry (FACScan). CT increased the expression of CD44, and ICAM-1 on alpha beta-TCR cells, whereas it did not affect any of the adhesion molecules on gamma delta- TCR cells. These findings suggest that CT is involved in the homing mechanism of CD4(+) alpha beta-TCR cells in the liver, via the expression of adhesion molecules. On the other hand, CT decreased significantly the absolute number of MNCs in the liver, and the relative number (%) of bright TCR cells (i.e. thymus-derived T cells) in the liver, thymus and spleen. However, CT increased the relative number of intermediate TCR cells (i.e. extrathymic T cells) in the liver. Significant decreases in the relative number of CD4(+) and alpha beta-TCR(+) cells in the liver after CT treatment were observed. Through expression of adhesion molecules on alpha beta-TCR cells in the liver, CT depresses the activity of bright TCR cells while activating intermediate TCR cells, and thus may exert an anti-rheumatic effect. |
