| First Author | Niehaus A | Year | 1999 |
| Journal | J Neurosci | Volume | 19 |
| Issue | 12 | Pages | 4948-61 |
| PubMed ID | 10366628 | Mgi Jnum | J:76139 |
| Mgi Id | MGI:2178705 | Doi | 10.1523/JNEUROSCI.19-12-04948.1999 |
| Citation | Niehaus A, et al. (1999) Cell-surface glycoprotein of oligodendrocyte progenitors involved in migration. J Neurosci 19(12):4948-61 |
| abstractText | Myelination by oligodendrocytes in the CNS involves the migration to and recognition and ensheathment of axons. These distinct developmental phases of myelination are assumed to involve the interplay of a precisely regulated set of cell adhesion molecules expressed by both neurons and glial cells. These molecules remain largely unelucidated. In this paper we have identified a large (330 kDa) glycoprotein expressed by murine oligodendrocyte progenitor cells in vitro and in vivo that is downregulated as oligodendrocytes mature. Antigen-positive oligodendrocyte progenitor cells purified by panning develop into myelin-associated glycoprotein-positive oligodendrocytes and also adhere to cultured neurons. Polyclonal antibodies directed against the protein reduce the migration of oligodendrocyte progenitor cells. The observations suggest that the AN2 antigen may play a role in early stages of myelination. |
