| First Author | Zhang P | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 5 | Pages | e97647 |
| PubMed ID | 24830702 | Mgi Jnum | J:216339 |
| Mgi Id | MGI:5608658 | Doi | 10.1371/journal.pone.0097647 |
| Citation | Zhang P, et al. (2014) Expression and function of kisspeptin during mouse decidualization. PLoS One 9(5):e97647 |
| abstractText | BACKGROUND: Plasma kisspeptin levels dramatically increased during the first trimester of human pregnancy, which is similar to pregnancy specific glycoprotein-human chorionic gonadotropin. However, its particular role in the implantation and decidualization has not been fully unraveled. Here, the study was conducted to investigate the expression and function of kisspeptin in mouse uterus during early pregnancy and decidualization. METHODOLOGY/PRINCIPAL FINDINGS: Quantitative PCR results demonstrated that Kiss1 and GPR54 mRNA levels showed dynamic increase in the mouse uterus during early pregnancy and artificially induced decidualization in vivo. KISS-1 and GPR54 proteins were spatiotemporally expressed in decidualizing stromal cells in intact pregnant females, as well as in pseudopregnant mice undergoing artificially induced decidualization. In the ovariectomized mouse uterus, the expression of Kiss1 mRNA was upregulated after progesterone or/and estradiol treatment. Moreover, in a stromal cell culture model, the expression of Kiss1 and GPR54 mRNA gradually rise with the progression of stromal cell decidualization, whereas the attenuated expression of Kiss1 using small interfering RNA approaches significantly blocked the progression of stromal cell decidualization. CONCLUSION: our results demonstrated that Kiss1/GPR54 system was involved in promoting uterine decidualization during early pregnancy in mice. |
