| First Author | Qi L | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 6 | Pages | 775-81 |
| PubMed ID | 23399934 | Mgi Jnum | J:195327 |
| Mgi Id | MGI:5477897 | Doi | 10.1016/j.febslet.2013.01.070 |
| Citation | Qi L, et al. (2013) miR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a. FEBS Lett 587(6):775-81 |
| abstractText | MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was characterized during mouse embryonic development, and was found to be stage- and tissue-specifically expressed. In addition, through luciferase reporter assays and western blot analyses, DNA methyltransferase 3A (Dnmt3a) was identified as a directly regulated target of miR-370. Altogether, our results indicate that miR-370 may play important roles in the morphogenesis of diverse organs, especially brain and adrenal glands, by mediating Dnmt3a expression during mouse development. |
