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Publication : Effects of life-long dietary protein restriction on mortality, growth, organ weights, blood counts, liver aldolase and kidney catalase in Balb/C mice.

First Author  Stoltzner G Year  1977
Journal  Growth Volume  41
Issue  4 Pages  337-48
PubMed ID  604178 Mgi Jnum  J:35647
Mgi Id  MGI:83096 Citation  Stoltzner G (1977) Effects of life-long dietary protein restriction on mortality, growth, organ weights, blood counts, liver aldolase and kidney catalase in Balb/C mice. Growth 41(4):337-48
abstractText  Certain types of nutritional restriction can prolong life in mammals. This investigation documents life long effects of five protein diets in 1,000 Balb/c male mice. Balb mice subjected to 4% protein (lowest) diet had life expectancy that was marginally significantly prolonged when compared with control mice fed 24% protein (highest) diet. Body and organ weights of protein restricted mice generally were less than control mice. No significant differences among diets were found with blood counts, protein concentrations of liver and kidneys, or kidney catalase activity. Kidney catalase activity fell with age. Liver aldolase was induced by dietary sucrose, and aldolase fell with age in protein restricted mice, but not in controls.
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