| First Author | Iimura T | Year | 1994 |
| Journal | Biochem Biophys Res Commun | Volume | 201 |
| Issue | 2 | Pages | 980-7 |
| PubMed ID | 7911662 | Mgi Jnum | J:19334 |
| Mgi Id | MGI:67505 | Doi | 10.1006/bbrc.1994.1798 |
| Citation | Iimura T, et al. (1994) Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein. Biochem Biophys Res Commun 201(2):980-7 |
| abstractText | Expression of homeobox genes in relation to ectopic bone formation induced by bone morphogenetic protein (BMP) was investigated. Oligonucleotide primers corresponding to highly conserved regions of Hox cluster and Msx genes were designed to detect homeobox sequences by means of the polymerase chain reaction (PCR). Nine rat homologues of Hox cluster genes and two Msx genes were discovered in the BMP-implanted tissue, at earlier stage and later cartilage and bone formation stage, respectively. The PCR study provided evidence of dynamic changes in BMP-induced homeobox gene expression. |
