| First Author | Ohsugi M | Year | 1996 |
| Journal | Dev Dyn | Volume | 206 |
| Issue | 4 | Pages | 391-402 |
| PubMed ID | 8853988 | Mgi Jnum | J:35077 |
| Mgi Id | MGI:82531 | Doi | 10.1002/(SICI)1097-0177(199608)206:4<391::AID-AJA5>3.0.CO;2-D |
| Citation | Ohsugi M, et al. (1996) Expression and cell membrane localization of catenins during mouse preimplantation development. Dev Dyn 206(4):391-402 |
| abstractText | We have studied transcription, expression, and membrane localization of components of the E-cadherin-catenin complex stage by stage during mouse preimplantation development. Maternal E-cadherin and alpha- and beta-catenin are stored as mRNA and/or protein in unfertilized eggs and are already assembled into a protein complex at this stage. After fertilization, it is likely that they mediate adhesion of early-stage blastomeres. Biosynthesis of plakoglobin is delayed relative to the other components. The temporal mRNA and protein expression patterns of the components of the cadherin-catenin complex correlate with the presence or absence of potential cytoplasmic polyadenylation elements (CPEs) in the 3'-UTRs of the respective cDNAs. Our results suggest that the components of the E-cadherin-catenin complex derived from both maternal and zygotic gene activity are increasingly accumulated and stored in a nonfunctional form during early cleavage stages and are ready to be used for compaction and the formation of the trophectodermal cell layer. |
