| First Author | Chappel MS | Year | 1996 |
| Journal | J Exp Med | Volume | 184 |
| Issue | 5 | Pages | 1639-49 |
| PubMed ID | 8920854 | Mgi Jnum | J:125136 |
| Mgi Id | MGI:3757615 | Doi | 10.1084/jem.184.5.1639 |
| Citation | Chappel MS, et al. (1996) Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J Exp Med 184(5):1638-49 |
| abstractText | The murine heat-stable antigen (HSA) is a glycosyl-phosphatidylinositol-linked cell surface protein which has been implicated in cellular adhesion processes, the co-stimulation of CD4+ T cells, and B cell memory. We have recently demonstrated a significant reduction in pro-B and pre-B lymphocytes in transgenic mice that overexpress HSA. We now report that cross-linking HSA with the M1/69 monoclonal antibody induces the apoptosis of cultured B cell precursors in a stomal cell and cytokine-independent manner and that sensitivity to HSA-mediated cell death increases with developmental maturity. The cross-linking of HSA does not induce apoptosis in mature splenic B cells, but instead inhibits their ability to proliferate in response to anti-CD40 + IL-4. Taken together, these data implicate HSA as a potent negative regulator of B cell development and activation. |
