| First Author | Liu Y | Year | 1992 |
| Journal | J Exp Med | Volume | 175 |
| Issue | 2 | Pages | 437-45 |
| PubMed ID | 1346270 | Mgi Jnum | J:125147 |
| Mgi Id | MGI:3757626 | Doi | 10.1084/jem.175.2.437 |
| Citation | Liu Y, et al. (1992) Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J Exp Med 175(2):437-45 |
| abstractText | Optimal induction of clonal expansion by normal CD4 T cells requires a ligand that can engage the T cell receptor as well as functionally defined costimulatory activity on the same antigen-presenting cell surface. While the presence of effective costimulation induces proliferation, T cell receptor ligation in its absence renders T cells inactive or anergic. The molecular basis of this costimulatory activity remains to be defined. Here we describe a monoclonal antibody that can block the costimulatory activity of splenic accessory cells. Treatment with this antibody not only blocks the proliferation of CD4 T cells to a T cell receptor ligand, but also induces T cell nonresponsiveness to subsequent stimulation. Sequence analysis of the antigen recognized by this antibody indicates that it recognizes a protein that is identical to heat-stable antigen. Gene transfer experiments directly demonstrate that this protein has costimulatory activity. Thus, heat-stable antigen meets the criteria for a costimulator of T cell clonal expansion. |
