| First Author | Gravestein LA | Year | 1998 |
| Journal | Eur J Immunol | Volume | 28 |
| Issue | 7 | Pages | 2208-16 |
| PubMed ID | 9692890 | Mgi Jnum | J:113841 |
| Mgi Id | MGI:3687722 | Doi | 10.1002/(SICI)1521-4141(199807)28:07<2208::AID-IMMU2208>3.0.CO;2-L |
| Citation | Gravestein LA, et al. (1998) The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2. Eur J Immunol 28(7):2208-16 |
| abstractText | CD27 is a lymphocyte-specific member of the TNF receptor (TNFR) family. It is a costimulatory molecule for peripheral T cells, as defined by its ability to enhance the TCR-induced proliferative response. We show here that CD27 augments TCR-induced Jun N-terminal kinase (JNK) activity in primary murine lymph node T cells. To investigate how CD27 couples to JNK, we performed a yeast two hybrid screen with the CD27 cytoplasmic tail. This revealed that CD27 directly associates with Traf-2. Transfection experiments using dominant negative Traf-2 indicated that CD27 communicates with JNK via Traf-2. These findings group CD27 together with other members of the TNFR family, TNFR-1, -2, CD30 and CD40, which have all been shown to couple to Traf proteins. Since Traf proteins have been reported to initiate an anti-apoptotic signaling pathway, our data suggest that CD27 not only regulates proliferation, but also survival of T lymphocytes. |
