| First Author | Shibata S | Year | 1997 |
| Journal | J Anat | Volume | 191 ( Pt 4) |
| Pages | 561-70 | PubMed ID | 9449075 |
| Mgi Jnum | J:45403 | Mgi Id | MGI:1195388 |
| Doi | 10.1046/j.1469-7580.1997.19140561.x | Citation | Shibata S, et al. (1997) Immunohistochemistry of collagen types II and X, and enzyme-histochemistry of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible. J Anat 191(Pt 4):561-70 |
| abstractText | We investigated the immunohistochemical localisation of types II and X collagen as well as the cytochemical localisation of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible on d 14-16 of pregnancy. On d 14 of pregnancy, although no immunostaining for types II and X collagen was observed, alkaline phosphatase activity was detected in all cells in the anlage of the future condylar process. On d 15 of pregnancy, immunostaining for both collagen types was simultaneously detected in the primarily formed condylar cartilage. Alkaline phosphatase activity was also detected in chondrocytes at this stage. By d 16 of pregnancy, the hypertrophic cell zone rapidly increased in size. These findings strongly support a periosteal origin for the condylar cartilage of the fetal mouse mandible, and show that progenitor cells for condylar cartilage rapidly or directly differentiate into hypertrophic chondrocytes. |
