| First Author | Tamási V | Year | 2003 |
| Journal | Cell Biol Int | Volume | 27 |
| Issue | 12 | Pages | 1011-5 |
| PubMed ID | 14642533 | Mgi Jnum | J:86914 |
| Mgi Id | MGI:2682458 | Doi | 10.1016/j.cellbi.2003.09.006 |
| Citation | Tamasi V, et al. (2003) Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice. Cell Biol Int 27(12):1011-5 |
| abstractText | Histamine is a biogenic amine with multiple physiological functions. Its importance in allergic inflammation is well characterized; moreover, it plays a role in the regulation of gastric acid production, various hypothalamic functions, such as food uptake, and enhancing TH2 balance during immune responses. Using histidine decarboxylase gene targeted (HDC(-/-)) BALB/c mice, we studied the effect of the absence of histamine on four cytochrome p450 enzyme activities. Their selective substrates were measured: ethoxyresorufin O-dealkylase activity of CYP1A, pentoxyresorufin O-dealkylase activity of CYP2B, chlorzoxazone 6-hydroxylase activity of CYP2E1 and ethylmorphine N-demethylase activity of CYP3A.The results indicate a significant elevation of CYP2E1 and CYP3A activities, however, no change in CYP1A and CYP2B activities was seen in HDC targeted mice compared to wild type controls with identical genetic backgrounds. |
